منابع مشابه
Parvin-ILK
Integrin-linked kinase (ILK), PINCH and Parvin proteins form the IPP-complex that has been established as a core component of the integrin-actin link. Our recent genetic studies on Drosophila parvin, reveal that loss of function mutant defects phenocopy those observed upon loss of ILK or PINCH in the muscle and the wing, strengthening the notion that these proteins function together in the orga...
متن کاملFunctional analysis of α-Parvin in vivo
The focal adhesion (FA) protein α-Parvin (αPv) has been shown to regulate integrin signalingand integrin-actin linkage. Here we report that the conditional deletion of the αPv gene inkeratinocytes leads to impaired hair follicle (HF) morphogenesis, epidermal hyperplasia andmicro-blistering. Expression of integrin α6 was reduced on αPv-deficient keratinocytes,leading to defects i...
متن کامل1 . 2 . Three - hit hypothesis in astrocytoma Parvin Mehdipour
Astrocytoma as a primary tumour is the core item in this section in which, by considering a pedigree-based research approach, the involvement of Ataxia-Telangiectasia (AT) gene is investigated. The two-hit -hypothesis of Knudson’s model is given to clarify the process of tumourigenesis in retinoblastoma. Lack of any available data for any hit hypothesis in brain tumours was the reason why the t...
متن کاملAlpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling.
During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide further vessel remodelling. Here, we show that loss of the focal adhesion (FA) protein alpha-parvin (alpha-pv) in mice leads to embryonic lethality due to severe cardiovascular defects. The vascular abnormalities are characterized by poor vess...
متن کاملPurification and SAXS Analysis of the Integrin Linked Kinase, PINCH, Parvin (IPP) Heterotrimeric Complex
The heterotrimeric protein complex containing the integrin linked kinase (ILK), parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts with many proteins to mediate signaling from integrin adhesion receptors. Here we conduct a biochemical and structural analysis of the minimal IPP complex, comprising full-length human ILK, the LIM1 d...
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ژورنال
عنوان ژورنال: Middle East Studies Association Bulletin
سال: 2005
ISSN: 0026-3184,2329-3233
DOI: 10.1017/s0026318400048768